The animal that regrows
its head
In a windowless lab at the
University of Galway in Ireland, there’s a fish tank containing an
extraordinary creature. Perched on blue cocktail sticks like lollipops, rows of
seashells are coated in a strange “living hair”, buffeted by gently flowing
seawater. This colony of tiny marine animals – known as “snail fur” – was
harvested in Irish rockpools off the backs of hermit crabs, and is related to
jellyfish, corals and sea anemones.
Each no bigger than a baby’s
eyelash, they are called Hydractinia, and up close resemble a tree, each with a
foot, a trunk and a tentacled head used for catching tasty passing detritus.
They also have a superpower: when grazing fish frequently bite off those
tentacle heads, they re-sprout to their former hirsute glory within a week.
The following picture depicts how
Hydractinia can grow back a new head:
It’s this talent that has captured
the attention of Uri Frank and colleagues at Galway’s Regenerative Medicine
Institute. Along with a growing number of researchers, he claims that the
tissue regeneration seen in creatures like Hydractinia could be an ancient
power possessed by most animals, including humans – it’s just dormant. So, how
does this “snail fur” regrow itself? And could it hold the key to tissue
regeneration in human beings too?
Many animals can regenerate body
parts, from starfish to salamanders. But primitive snail fur is unusual, not
least because its abilities are so extreme.
Marshalling stem cells
The key to Hydractinia’s
regenerative talent is the fact that it retains its embryonic stem cells for
life. This means that any wound healing process doesn’t just produce a scab and
a scar but a whole new body part as it would in an embryo, even a head.
At a gathering of developmental
biologists earlier this year, Frank showed a video of the creature’s
head-budding process in action, embryonic stem cells that had been genetically
altered to glow green rushing to the neck end of a headless Hydractinia. Attendees
were agog. As one tweeted: “Uri Frank shows timelapse movie of Hydractinia stem
cells physically moving across to head (wound site) – Wow!”
Since recording that video the
Galway team have been working to understand how Hydractinia rebuilds its severed
body and hope to publish their findings shortly in a scientific journal. While
they’re keeping schtum about the details, the paper will focus on how the
creature marshalls its stem cells to regrow its head – for example, how stem
cells know the head’s missing – and where exactly the embryonic stem cells come
from.
Studying Hydractinia has also led
Frank and colleagues to ask a bigger question: why can only a few animals
regenerate while most can’t? A salamander can regrow a lost tail but closely
related frogs can’t regrow a lost limb. And if a tiny marine creature can
regrow its own head, why can’t humans even regrow their adult teeth? After all,
says Frank, it’s not as if human and Hydractinia stem cell systems are so very
different.
Key stem cell processes are
ancient and common to many animal species. For instance, the complex “Wnt”
signalling system, which controls stem cells in developing embryos and, when
uncontrolled, causes cancer, is very similar in all animals, including
Hydractinia and people. It’s one of a handful of complex stem cell systems,
each involving hundreds of elements, which have remained the same since
Hydractinia branched off the evolutionary tree that eventually led to us around
600 million years ago.
Over the past decade or so,
researchers have started to believe that stem cells first evolved in a creature
even more ancient than Hydractinia, whose soft body has long since dissolved in
ancient seabeds. In this as-yet-unknown creature, the power of regeneration may
have first evolved, says Frank, endowing all later animals with a basic toolkit
for regrowing lost body parts – one which mainly lies dormant in present-day
life.
“It’s maybe not such a crazy idea.
Stem cell systems are enormously complex and 600 million years may not be long
enough to reinvent another system from scratch. So it’s more likely to believe
that our stem cell system and Hydractinia’s stem cell system were actually
inherited from a common ancestor,” says Frank. “And if you think about it,
Hydractinia can grow a new head and, although we cannot as adults, we can do
that as embryos when we make our own head. So it is possible that this ability
to do so is switched off in human adults and in Hydractinia it’s not.”
This theory ties in with a study
published last year in the journal Nature, about two varieties of an ancient
form of flatworm, the planarian. This worm has been studied for over a century
because of its amazing regenerative powers. Slice them up into tiny pieces and
some planarian worms can regrow their bodies from even the tiniest tailpiece.
Others need most of their body intact to regrow a head. Until now, that is.
Researchers at the Max Planck
Institute tested the idea that all planarian flatworms have the same
regenerative superpowers but that in some it’s switched off early in
development. They were right. With a relatively simple tweak to the stem cell
system of a developing embryo they turned a creature that in nature couldn’t
regrow a head out of a tiny tailpiece, into one that could.
In Galway, Frank hopes his
research will help to explain the apparently miraculous results from planarian
experiments and unravel other mysteries, too. Why, for instance, do planarians
easily grow new tails when Hydractinia struggles to regrow its foot? One idea
is that body symmetry - front/back or left-right as in planarians and humans
but not snail fur – may dictate where stem cells in the body can migrate to.
In theory, it’s possible that
humans may harbour the same dormant regenerative superpowers as snail fur and
flatworms, however far they seem from humans. At the most basic cellular level
there are striking similarities. Studying them could teach us how to regrow
damaged or lost body parts too. “While there’s no market for regrowing human
heads,” says Frank, “wouldn’t it be great if we could repair spinal cords,
damaged hearts, damaged kidneys, hands and any other organs we might lose?”
The flatworm studies imply this
might not be quite as unthinkable as once thought. The Victorian father of
regenerative science, Thomas Hunt Morgan carried out flatworm experiments
showed their amazing powers to regrow a whole body from a stump in 1901. But he
abandoned the study, writing: “We will never understand the phenomena of
development and regeneration.”
Clearly, there are many mysteries
of regeneration still to be revealed, yet now it seems that a tiny creature
living in a fish tank in Galway and its ilk could help us unlock the bizarre
process of regrowing body parts sooner than we thought.
Questions 1-5
Do
the following statements agree with the information in the IELTS reading text?
In
boxes 1-5 on your answer sheet, write
TRUE
if the statement agrees with the information
FALSE
if the statement contradicts the information
NOT GIVEN
if there is no information on this
1. "Snail fur" is related to jellyfish, corals and
sea anemones
2. Judging by the picture, Hydractinia can regrow its head in a
day
3. Uri Frank thinks that even humans can possess regenerating
powers.
4. Snail fur is similar to salamnders and starfish.
5. Healing in Hydractinia produces new body part.
Questions 6-9
Choose
the correct letter, A, B, C or D.
Write
the correct letter in boxes 6-9 on your answer sheet.
6. Which of the following DIDN'T happen at a
gathering of developmental biologists?
- Uri
Frank showed a video of Hydractinia regenerating its head.
- Some
stem sells of the creature were glowing green.
- Attendants
were astonished by the show.
- Research
conference afterwards took place.
7. The Galway team will focus on what in their future paper?
- How
Hydractinia manages to regrow its head.
- How
stem cells know that the head is missing.
- Where
the stem cells come from.
- All
of the above.
8. According to Frank Uri and his team
- human
and Hydractinia stem cells are similar.
- most
organisms can regenerate themselves.
- frogs
can regrow lost limbs.
- salamander
and frogs are not closely related.
Questions 9-13
Complete
the sentences below.
Write ONLY
ONE WORD from the passage for each answer.
Write
your answers in boxes 9-13 on your answer sheet.
9. “Wnt” signalling system can cause ……… if uncontrolled.
10. Human and Hydractinia stem cells might actually be from a common………. .
11. The thing that dictates where stem cells in the body can migrate
tomight be body……………...
12. Humans might possibly harbour the same ……….. regenerative superpowers as snail
fur and flatworms.
13.Thomas Hunt Morgan said that we will never understand the ………… of development and regeneration.
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